Publications

2026

2025

• HIV-1 Vif and Vpr cooperatively modulate the cell cycle to maximize per-cell virion production. Bandini M, Ghone D, Evans EL 3rd, Suzuki A, Sherer NM. Proc Natl Acad Sci U S A. 2025 Nov 11;122(45):e2511502122. doi: 10.1073/pnas.2511502122. Epub 2025 Nov 6. PMID: 41196352
• HIV-1 Vif disrupts phosphatase feedback regulation at the kinetochore, leading to a pronounced pseudo-metaphase arrest. Ghone D, Evans EL, Bandini M, Stephenson KG, Sherer NM, Suzuki A. Elife. 2025 Mar 13;13:RP101136. doi: 10.7554/eLife.101136. PMID: 40080415; PMCID: PMC11906157.
• HIV-1 single-transcription start-site mutants display complementary replication functions that are restored by reversion. Gc K, Lesko S, Emery A, Burnett C, Gopal K, Clark S, Swanstrom R, Sherer NM, Telesnitsky A, Kharytonchyk S. J Virol. 2025 Mar 4:e0213924. doi: 10.1128/jvi.02139-24. Epub ahead of print. PMID: 40035516.
• Single-cell delineation of strain-specific HIV-1 Vif activities using dual reporter sensor cells and live cell imaging. Guerrero JF, Zimdars LL, Bruce JW, Becker JT, Evans EL 3rd, Torabi S, Striker R, Berry SM, Sherer NM. J Virol. 2025 Mar 18;99(3):e0157924. doi: 10.1128/jvi.01579-24. Epub 2025 Feb 25. PMID: 39998123; PMCID: PMC11915839.
• One step 4x and 12x 3D-ExM enables robust super-resolution microscopy of nanoscale cellular structures. Norman RX, Chen YC, Recchia EE, Loi J, Rosemarie Q, Lesko SL, Patel S, Sherer N, Takaku M, Burkard ME, Suzuki A. J Cell Biol. 2025 Feb 3;224(2):e202407116. doi: 10.1083/jcb.202407116. Epub 2024 Dec 3. PMID: 39625433; PMCID: PMC11613959.

2024

• Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation. Yasin S, Lesko SL, Kharytonchyk S, Brown JD, Chaudry I, Geleta SA, Tadzong NF, Zheng MY, Patel HB, Kengni G, Neubert E, Quiambao JMC, Becker G, Ghinger FG, Thapa S, Williams A, Radov MH, Boehlert KX, Hollmann NM, Singh K, Bruce JW, Marchant J, Telesnitsky A, Sherer NM, Summers MF. Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2407400121. doi: 10.1073/pnas.2407400121. Epub 2024 Aug 7. PMID: 39110735; PMCID: PMC11331132.
• Topical Protease Inhibitor Increases Tumor-Free and Overall Survival in CD4-Depleted Mouse Model of Anal Cancer.
  Yao E, Gunder L, Moyer T, Matkowskyj KA, Fox K, Zhou Y, Haggerty S, Johnson H, Sherer N, Carchman E. Viruses. 2024 Sep 5;16(9):1421. doi: 10.3390/v16091421. PMID: 39339897
• Identification of host proteins involved in Hepatitis B virus genome packaging. Whitworth IT, Romero S, Kissi-Twum A, Knoener R, Scalf M, Sherer NM, Smith LM. J Proteome Res. 2024 Sep 6;23(9):4128-4138. doi: 10.1021/acs.jproteome.4c00505. Epub 2024 Jul 30. PMID: 39078123; PMCID: PMC11693245.
• Studying Retroviral Life Cycles Using Visible Viruses and Live Cell Imaging. Guerrero JF, Lesko SL, Evans EL, Sherer NM. Annu Rev Virol. 2024 Sep;11(1):125-146. doi: 10.1146/annurev-virology-100422-012608. Epub 2024 Aug 30. PMID: 38876144

• Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV^± cancer. Ayuso JM, Farooqui M, Virumbrales-Muñoz M, Denecke K, Rehman S, Schmitz R, Guerrero JF, Sanchez-de-Diego C, Campo SA, Maly EM, Forsberg MH, Kerr SC, Striker R, Sherer NM, Harari P, Capitini CM, Skala MC, Beebe DJ. Nat Commun. 2023 Oct 21;14(1):6681. doi: 10.1038/s41467-023-41625-8. PMID: 37865647
• Exploiting a rodent cell block for intrinsic resistance to HIV-1 gene expression in human T cells. Behrens RT, Rajashekar JK, Bruce JW, Evans EL 3rd, Hansen AM, Salazar-Quiroz N, Simons LM, Ahlquist P, Hultquist JF, Kumar P, Sherer NM. mBio. 2023 Sep 7:e0042023. doi: 10.1128/mbio.00420-23. Online ahead of print. PMID: 37676006
• Retroviral hijacking of host transport pathways for genome nuclear export.
  Behrens RT, Sherer NM. mBio. 2023 Dec 19;14(6):e0007023. doi: 10.1128/mbio.00070-23. Epub 2023 Nov 1. PMID: 37909783
• HIV-1 virological synapse formation enhances infection spread by dysregulating Aurora Kinase B. Bruce JW, Park E, Magnano C, Horswill M, Richards A, Potts G, Hebert A, Islam N, Coon JJ, Gitter A, Sherer N, Ahlquist P. PLoS Pathog. 2023 Jul 17;19(7):e1011492. doi: 10.1371/journal.ppat.1011492. eCollection 2023 Jul. PMID: 37459363
• Defining distinct RNA-protein interactomes of SARS-CoV-2 genomic and subgenomic RNAs. Whitworth IT, Knoener RA, Puray-Chavez M, Halfmann P, Romero S, Baddouh M, Scalf M, Kawaoka Y, Kutluay SB, Smith LM, Sherer NM. bioRxiv. 2023 May 16:2023.05.15.540806. doi: 10.1101/2023.05.15.540806. Preprint. PMID: 37293069
• Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease. Gunder LC, Johnson HR, Yao E, Moyer TH, Green HA, Sherer N, Zhang W, Carchman EH. Viruses. 2023 Apr 20;15(4):1013. doi: 10.3390/v15041013. PMID: 37112993
• Live Cell Imaging Reveals HBV Capsid Translocation from the Nucleus To the Cytoplasm Enabled by Cell Division. Romero S, Unchwaniwala N, Evans EL 3rd, Eliceiri KW, Loeb DD, Sherer NM. mBio. 2023 Apr 25;14(2):e0330322. doi: 10.1128/mbio.03303-22. Epub 2023 Feb 21. PMID: 36809075
• Human lysyl-tRNA synthetase phosphorylation promotes HIV-1 proviral DNA transcription.
  Tang Y, Behrens RT, St Gelais C, Wu S, Vivekanandan S, Razin E, Fang P, Wu L, Sherer N, Musier-Forsyth K. Nucleic Acids Res. 2023 Dec 11;51(22):12111-12123. doi: 10.1093/nar/gkad941. PMID: 37933844

2022

• HIV RGB: Automated Single-Cell Analysis of HIV-1 Rev-Dependent RNA Nuclear Export and Translation Using Image Processing in KNIME. Evans EL 3rd, Pocock GM, Einsdorf G, Behrens RT, Dobson ETA, Wiedenmann M, Birkhold C, Ahlquist P, Eliceiri KW, Sherer NM. Viruses. 2022 Apr 26;14(5):903. doi: 10.3390/v14050903. PMID: 35632645
• Discovery of Dehydroamino Acid Residues in the Capsid and Matrix Structural Proteins of HIV-1. Miller RM, Knoener RA, Benner BE, Frey BL, Scalf M, Shortreed MR, Sherer NM, Smith LM. J Proteome Res. 2022 Apr 1;21(4):993-1001. doi: 10.1021/acs.jproteome.1c00867. Epub 2022 Feb 22. PMID: 35192358
• Perturbing HIV-1 Ribosomal Frameshifting Frequency Reveals a cis Preference for Gag-Pol Incorporation into Assembling Virions. Benner BE, Bruce JW, Kentala JR, Murray M, Becker JT, Garcia-Miranda P, Ahlquist P, Butcher SE, Sherer NM. J Virol. 2022 Jan 12;96(1):e0134921. doi: 10.1128/JVI.01349-21. Epub 2021 Oct 13. PMID: 3464342
• Mediator complex subunit 12 is a gatekeeper of SARS-CoV-2 infection in breast cancer cells. Zhang S, Liu F, Halfmann P, Behrens RT, Liu P, Mcilwain SJ, Ong IM, Donahue K, Wang Y, Kawaoka Y, Sherer N, Xu W. Genes Dis. 2022 Jan;9(1):5-8. doi: 10.1016/j.gendis.2021.08.001. Epub 2021 Aug 17. PMID: 34423104

2021

• HIV-1 Protease Inhibitors Slow HPV16-Driven Cell Proliferation through Targeted Depletion of Viral E6 and E7 Oncoproteins. Park S, Auyeung A, Lee DL, Lambert PF, Carchman EH, Sherer NM. Cancers (Basel). 2021 Feb 24;13(5):949. doi: 10.3390/cancers13050949. PMID: 33668328
• ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses. Bruce JW, Bracken M, Evans E, Sherer N, Ahlquist P. PLoS Pathog. 2021 Feb 26;17(2):e1009364. doi: 10.1371/journal.ppat.1009364. eCollection 2021 Feb. PMID: 33635925
• Identification of host proteins differentially associated with HIV-1 RNA splice variants. Knoener R, Evans E 3rd, Becker JT, Scalf M, Benner B, Sherer NM, Smith LM. Elife. 2021 Feb 25;10:e62470. doi: 10.7554/eLife.62470. PMID: 33629952
• New Extensibility and Scripting Tools in the ImageJ Ecosystem. Gahm NA, Rueden CT, Evans EL 3rd, Selzer G, Hiner MC, Chacko JV, Gao D, Sherer NM, Eliceiri KW. Curr Protoc. 2021 Aug;1(8):e204. doi: 10.1002/cpz1.204. PMID: 34370407

2020

• Integration of the ImageJ Ecosystem in the KNIME Analytics Platform. Dietz C, Rueden CT, Helfrich S, Dobson ETA, Horn M, Eglinger J, Evans EL 3rd, McLean DT, Novitskaya T, Ricke WA, Sherer NM, Zijlstra A, Berthold MR, Eliceiri KW. Front Comput Sci. 2020 Mar;2:8. doi: 10.3389/fcomp.2020.00008. Epub 2020 Mar 17. PMID: 32905440
• B cells infected with Type 2 Epstein-Barr virus (EBV) have increased NFATc1/NFATc2 activity and enhanced lytic gene expression in comparison to Type 1 EBV infection. Romero-Masters JC, Huebner SM, Ohashi M, Bristol JA, Benner BE, Barlow EA, Turk GL, Nelson SE, Baiu DC, Van Sciver N, Ranheim EA, Gumperz J, Sherer NM, Farrell PJ, Johannsen EC, Kenney SC. PLoS Pathog. 2020 Feb 14;16(2):e1008365. doi: 10.1371/journal.ppat.1008365. eCollection 2020 Feb. PMID: 32059024

2019

• Antigen structure affects cellular routing through DC-SIGN. Jarvis CM, Zwick DB, Grim JC, Alam MM, Prost LR, Gardiner JC, Park S, Zimdars LL, Sherer NM, Kiessling LL. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14862-14867. doi: 10.1073/pnas.1820165116. Epub 2019 Jul 3. PMID: 31270240
• Spatially Adaptive Colocalization Analysis in Dual-Color Fluorescence Microscopy. Wang S, Arena ET, Becker JT, Bement WM, Sherer NM, Eliceiri KW, Yuan M. IEEE Trans Image Process. 2019 Apr 4. doi: 10.1109/TIP.2019.2909194. Online ahead of print. PMID: 30951467
• The Polar Region of the HIV-1 Envelope Protein Determines Viral Fusion and Infectivity by Stabilizing the gp120-gp41 Association. Lu W, Chen S, Yu J, Behrens R, Wiggins J, Sherer N, Liu SL, Xiong Y, Xiang SH, Wu L. J Virol. 2019 Mar 21;93(7):e02128-18. doi: 10.1128/JVI.02128-18. Print 2019 Apr 1. PMID: 30651369

2018

• LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes. Sharma A, Lawry SM, Klein BS, Wang X, Sherer NM, Zumwalde NA, Gumperz JE. J Immunol. 2018 Oct 15;201(8):2452-2461. doi: 10.4049/jimmunol.1800537. Epub 2018 Aug 31. PMID: 30171164
• HIV-1 Vif’s Capacity To Manipulate the Cell Cycle Is Species Specific. Evans EL 3rd, Becker JT, Fricke SL, Patel K, Sherer NM. J Virol. 2018 Mar 14;92(7):e02102-17. doi: 10.1128/JVI.02102-17. Print 2018 Apr 1. PMID: 29321323

2017

• Elucidating the in vivo interactome of HIV-1 RNA by hybridization capture and mass spectrometry. Knoener RA, Becker JT, Scalf M, Sherer NM, Smith LM. Sci Rep. 2017 Dec 5;7(1):16965. doi: 10.1038/s41598-017-16793-5. PMID: 29208937
• Differential Disruption of Nucleocytoplasmic Trafficking Pathways by Rhinovirus 2A Proteases. Watters K, Inankur B, Gardiner JC, Warrick J, Sherer NM, Yin J, Palmenberg AC. J Virol. 2017 Mar 29;91(8):e02472-16. doi: 10.1128/JVI.02472-16. Print 2017 Apr 15. PMID: 28179529
• Subcellular Localization of HIV-1 gag-pol mRNAs Regulates Sites of Virion Assembly. Becker JT, Sherer NM. J Virol. 2017 Feb 28;91(6):e02315-16. doi: 10.1128/JVI.02315-16. Print 2017 Mar 15. PMID: 28053097
• Diverse activities of viral cis-acting RNA regulatory elements revealed using multicolor, long-term, single-cell imaging. Pocock GM, Zimdars LL, Yuan M, Eliceiri KW, Ahlquist P, Sherer NM. Mol Biol Cell. 2017 Feb 1;28(3):476-487. doi: 10.1091/mbc.E16-08-0612. Epub 2016 Nov 30. PMID: 27903772
• Nuclear Export Signal Masking Regulates HIV-1 Rev Trafficking and Viral RNA Nuclear Export. Behrens RT, Aligeti M, Pocock GM, Higgins CA, Sherer NM. J Virol. 2017 Jan 18;91(3):e02107-16. doi: 10.1128/JVI.02107-16. Print 2017 Feb 1. PMID: 27852860

2016

• Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs. Xu X, Pocock GM, Sharma A, Peery SL, Fites JS, Felley L, Zarnowski R, Stewart D, Berthier E, Klein BS, Sherer NM, Gumperz JE. Cell Rep. 2016 Sep 20;16(12):3273-3285. doi: 10.1016/j.celrep.2016.08.061. PMID: 27653689
• Hepatitis B Virus Polymerase Localizes to the Mitochondria, and Its Terminal Protein Domain Contains the Mitochondrial Targeting Signal. Unchwaniwala N, Sherer NM, Loeb DD. J Virol. 2016 Sep 12;90(19):8705-19. doi: 10.1128/JVI.01229-16. Print 2016 Oct 1. PMID: 27440888
• Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer. Brinkman AM, Chen G, Wang Y, Hedman CJ, Sherer NM, Havighurst TC, Gong S, Xu W. Biomaterials. 2016 Sep;101:20-31. doi: 10.1016/j.biomaterials.2016.05.041. Epub 2016 May 27. PMID: 27267625
• Stability of HIV Frameshift Site RNA Correlates with Frameshift Efficiency and Decreased Virus Infectivity. Garcia-Miranda P, Becker JT, Benner BE, Blume A, Sherer NM, Butcher SE. J Virol. 2016 Jul 11;90(15):6906-6917. doi: 10.1128/JVI.00149-16. Print 2016 Aug 1. PMID: 27194769
• HIV-1 Gag, Envelope, and Extracellular Determinants Cooperate To Regulate the Stability and Turnover of Virological Synapses. Gardiner JC, Mauer EJ, Sherer NM. J Virol. 2016 Jun 24;90(14):6583-6597. doi: 10.1128/JVI.00600-16. Print 2016 Jul 15. PMID: 27170746
• HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors. Pocock GM, Becker JT, Swanson CM, Ahlquist P, Sherer NM. PLoS Pathog. 2016 Apr 12;12(4):e1005565. doi: 10.1371/journal.ppat.1005565. eCollection 2016 Apr. PMID: 27070420
• N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA. Hilimire TA, Bennett RP, Stewart RA, Garcia-Miranda P, Blume A, Becker J, Sherer N, Helms ED, Butcher SE, Smith HC, Miller BL. ACS Chem Biol. 2016 Jan 15;11(1):88-94. doi: 10.1021/acschembio.5b00682. Epub 2015 Nov 3. PMID: 26496521

2015

• Differential CARM1 Isoform Expression in Subcellular Compartments and among Malignant and Benign Breast Tumors. Shlensky D, Mirrielees JA, Zhao Z, Wang L, Mahajan A, Yu M, Sherer NM, Wilke LG, Xu W. PLoS One. 2015 Jun 1;10(6):e0128143. doi: 10.1371/journal.pone.0128143. eCollection 2015. PMID: 26030442 Free PMC article.
• O-GlcNAcylation of co-activator-associated arginine methyltransferase 1 regulates its protein substrate specificity. Charoensuksai P, Kuhn P, Wang L, Sherer N, Xu W. Biochem J. 2015 Mar 15;466(3):587-99. doi: 10.1042/BJ20141072. PMID: 25585345

2014

• Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism. Aligeti M, Behrens RT, Pocock GM, Schindelin J, Dietz C, Eliceiri KW, Swanson CM, Malim MH, Ahlquist P, Sherer NM. J Virol. 2014 Dec;88(24):14207-21. doi: 10.1128/JVI.01897-14. Epub 2014 Oct 1. PMID: 25275125
• Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes. Li F, Sewald X, Jin J, Sherer NM, Mothes W. J Virol. 2014 Sep;88(18):10541-55. doi: 10.1128/JVI.01104-14. Epub 2014 Jun 25. PMID: 24965475

2013

• Long-distance relationships: do membrane nanotubes regulate cell-cell communication and disease progression? Sherer NM. Mol Biol Cell. 2013 Apr;24(8):1095-8. doi: 10.1091/mbc.E12-08-0622. PMID: 23580190